Developing chemogenetic strategies in nonhuman primates to assess the role of amygdala function in pathological anxiety
Save as calendar entryAnxiety disorders (ADs) are among the most prevalent psychiatric disorders, with symptoms often beginning early in life. The amygdala is a key component of the neural circuitry that mediates stress-related responses across species, and human neuroimaging studies have demonstrated altered amygdala activity in individuals with ADs. To further investigate the role of the primate amygdala in the expression of anxiety, we used a chemogenetic approach, Designer Receptors Exclusively Activated by Designer Drugs (DREADDs), to reversibly manipulate amygdala neuronal function in a rhesus model of pathological anxiety. In this talk, I will review our behavioral, immunohistochemical, and PET imaging results, as well as share some insight into our exploration of viral methods to achieve selective DREADD expression within NHP neuronal subpopulations.
Referent
Sascha Ziegler (Magdeburg)
Journey Description
Map
E - Main Entrance/Reception
1 - Managing Board; sections: Infection Biology Unit, Unit of Infection Models, Laboratory Animal Science Unit, Primate Genetics Laboratory, Behavioral Ecology and Sociobiology Unit, Cognitive Ethology Laboratory, Neurobiology Laboratory, Research Coordination, Public Relations, Information Technology, Administration, Technical Support, Library.
2 - Material Delivery/Purchase
3 - Platform Degenerative Diseases
4 - Cognitive Neuroscience Laboratory
5 - Animal Husbandry
6 - Imaging Center, Functional Imaging Laboratory
Arrival by car
Leave the interstate A7 at exit "Göttingen Nord". Follow the B27 straight ahead in the direction of "Braunlage". After the third traffic light intersection turn right towards "Kliniken". Afterwards turn left onto "Robert-Koch-Straße" direction "Universität Nordbereich/Polizei". At the end of "Robert-Koch-Straße" turn right onto "Otto-Hahn-Straße", direction "Nikolausberg". The first street on the left turn onto "Kellnerweg", follow the signs "Deutsches Primatenzentrum".
Arrival by bus
The footpath from the bus stop "Kellnerweg" to the Main Entrance/Reception:
From Bus stop "Kellnerweg" (line 21/22 and 23) Cross the road, go in the direction of the bus. At the mailbox, turn left into the footpath and proceed to the end. Turn right into the Kellnerweg. The main entrance of the DPZ is on the left side.
Date and Time 26.04.24 - 13:00 Signup is not required
Location Michael-Lankeit Lecture Hall, German Primate Center
Decision and Awareness Group, Cognitive Neurosciences Lab
ikagan@dpz.eu