Revolutionizing Primate Neuroscience with Imaging-Guided Chemogenetics
Save as calendar entryNonhuman primates (NHPs), especially macaque and marmoset monkeys, are excellent models for elucidating highly organized brain function and behavior. However, the ability to manipulate and study these brains at a network level is currently limited due to the lack of genetic neuromodulation tools available. To bridge this gap, our team has been exploring the use of chemogenetic technology known as Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) in NHPs. DREADDs provide a means to reversibly and remotely control the activity of a neuronal population expressing designer receptors through delivery of their agonist. By combining DREADDs with PET and MR imaging, we have developed a powerful tool for NHP research that enables the visualization and manipulation of specific brain circuits, and the monitoring of changes in network activity. This technology provides exciting prospects for understanding the link between primate brain circuits and behavior, as well as the development of therapeutic applications. In this talk, I will introduce our pioneering imaging-guided chemogenetic strategies and present new insights into the functions of primate prefronto-subcortical circuits.
Referent
Takafumi Minamimoto (National Institutes for Quantum Science and Technology, Japan)
Journey Description
Map
E - Main Entrance/Reception
1 - Managing Board; sections: Infection Biology Unit, Unit of Infection Models, Laboratory Animal Science Unit, Primate Genetics Laboratory, Behavioral Ecology and Sociobiology Unit, Cognitive Ethology Laboratory, Neurobiology Laboratory, Research Coordination, Public Relations, Information Technology, Administration, Technical Support, Library.
2 - Material Delivery/Purchase
3 - Platform Degenerative Diseases
4 - Cognitive Neuroscience Laboratory
5 - Animal Husbandry
6 - Imaging Center, Functional Imaging Laboratory
Arrival by car
Leave the interstate A7 at exit "Göttingen Nord". Follow the B27 straight ahead in the direction of "Braunlage". After the third traffic light intersection turn right towards "Kliniken". Afterwards turn left onto "Robert-Koch-Straße" direction "Universität Nordbereich/Polizei". At the end of "Robert-Koch-Straße" turn right onto "Otto-Hahn-Straße", direction "Nikolausberg". The first street on the left turn onto "Kellnerweg", follow the signs "Deutsches Primatenzentrum".
Arrival by bus
The footpath from the bus stop "Kellnerweg" to the Main Entrance/Reception:
From Bus stop "Kellnerweg" (line 21/22 and 23) Cross the road, go in the direction of the bus. At the mailbox, turn left into the footpath and proceed to the end. Turn right into the Kellnerweg. The main entrance of the DPZ is on the left side.
Date and Time 26.04.24 - 11:00 Signup is not required
Location Michael-Lankeit Lecture Hall, German Primate Center
Leibniz ScienceCampus Primate Cognition
cschloegl@dpz.eu
0551-3851-480